TWO EBOLA DRUGS FOUND

Two Ebola drugs found to increase survival rates

By Mukayi Sam

More than 1,800 people have died in eastern Democratic Republic of Congo since Ebola broke out there in August last year.

A girl receives a vaccine against Ebola from a nurse in Goma on August 7, 2019.
A girl receives a vaccine against Ebola from a nurse in Goma on August 7, 2019. (AFP)
Scientists are a step closer to finding the first effective treatments for the deadly Ebola haemorrhagic fever after two potential drugs showed a survival rate of as much as 90% in a clinical trial in the Democratic Republic of Congo (DRC), the US health authority co-funding the research said Monday.
Two experimental drugs –– Regen eron's REGN-EB3 and a monoclonal antibody called mAb114 –– were both developed using antibodies harvested from survivors of Ebola infection.
The treatments are now going to be offered to all patients in DRC, according to the US National Institutes of Health (NIH).
REGN-EB3 and mAb114 "are the first drugs that, in a scientifically sound study, have clearly shown a significant diminution in mortality for people with Ebola virus disease," Anthony Fauci, director of NIH's National Institute of Allergy and Infectious Diseases, said.
They showed "clearly better" results in patients in a trial of four potential treatments being conducted during the world's second-largest Ebola outbreak in history, now entering its second year in DRC.
The study began last November in the Democratic Republic of Congo, but its current phase has been halted and all future patients switched over to the treatments that have shown positive results, National Institute of Allergy and Infectious Diseases said in a statement.
The drugs improved survival rates from the disease more than two other treatments being tested –– ZMapp, made by Mapp Biopharmaceutical, and Remdesivir, made by Gilead Sciences –– and those products will be now dropped, Fauci, one of the researchers co-leading the trial, said.
Fauci explained that the trial was designed to include 725 people, but was halted by an independent board when it had enrolled 681 people because at that point, one of the drugs, REGN-EB3 by Regeneron, reached a critical threshold in success, while mAb114 was not far behind.
Data has so far been analyzed for 499 people from the cohort of 681.
In this group, mortality dropped to 29 per cent with REGN-EB3 and with mAb114 it fell to 34 per cent, said Fauci –– compared to a rate of between 60 and 67 per cent in the general population when the disease is not treated by a drug.
The rates for Zmapp and Remdesivir were 49 per cent and 53 per cent respectively.
REGN-EB3, mAb114 and Zmapp are monoclonal antibodies that bind to glycoprotein on the Ebola virus and neutralise its ability to infect other cells.
Fauci added that the final analysis of the data, including the patients not yet processed, would occur in late September or early October, after which the complete results would be submitted for publication in peer-reviewed medical literature.
The NIH, Democratic Republic of Congo health authorities and the World Health Organization hailed the "extraordinary team of individuals who have worked under extremely difficult conditions to carry out this study," as well as the patients and their families.
Vaccine still key 
Jeremy Farrar, director of Britain's Wellcome Trust research charity, said the development would "undoubtedly save lives," adding: "Thanks to this trial, we are starting to understand which treatments to offer to patients in this and future outbreaks."
Let me know what you think about this discovery in the comments below

Comments